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May 25 to May 29, 2009

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AT A GLANCE - MEETINGS AT NIST

MONDAY - 5/25
No Scheduled Events
TUESDAY - 5/26
10:30 AM - Vertical Molecular Transistors
3:00 PM - Opportunities for Spectroscopic Analysis of Breast Tissue in Epidemiologic Studies
WEDNESDAY - 5/27
10:00 AM - Uncertainty Budget for Range Calibration
10:30 AM - Factors Affecting Detection of Pathogenic E. coli and Salmonella in Mixed Cultures
THURSDAY - 5/28
10:30 AM - Structure/Function Studies on Bacteriophage Lysins
10:30 AM - DEVELOPMENT OF A SCANNING TUNNELING POTENTIOMETRY SYSTEM FOR MEASUREMENT OF ELECTRONIC TRANSPORT AT SHORT LENGTH SCALES
FRIDAY - 5/29
10:30 AM - Quantum Complexity and Fundamental Physics
10:45 AM - High Power Fuel Cells and Lithium Ion Batteries
1:30 PM - Manipulating Motion with Light: Optical Gradient Forces in Double-disk Microcavities

MEETINGS AT NIST

5/25 -- MONDAY

No Scheduled Events

5/26 -- TUESDAY

10:30 AM - CNST NANOFABRICATION RESEARCH GROUP SEMINAR: Vertical Molecular Transistors
We demonstrate a universal method in which a new type of nanometer-sized, ambipolar, vertical molecular transistor is fabricated in parallel fashion. This Central-Gate Molecular Vertical Transistor (C-Gate MolVeT) is fabricated by a combination of conventional micro-lithography techniques and self-assembly methods. Here we will show several examples which utilize this device to investigate transport phenomena on the molecular scale.
Shachar Richter , School of Chemistry and University Center for Nanoscience and Nanotechnology,Tel Aviv University,.
Bldg. 217, Rm H107. (NIST Contact: Nikolai Zhitenev, 301-975-6039, nikolai.zhitenev@nist.gov)


3:00 PM - OPTICAL TECHNOLOGY DIVISION/ BIOPHYSICS GROUP: Opportunities for Spectroscopic Analysis of Breast Tissue in Epidemiologic Studies
Epidemiologic studies have identified numerous risk factors for breast cancer, including the recent identification of genetic susceptibility loci. Data suggest that breast cancer is a heterogeneous disease that can be parsed into subtypes based on histopathology, molecular markers, basic biology or clinical behavior. One goal of etiologic research is to relate risk factors to the mechanisms that mediate their action and lead to tumors with distinctive phenotypes. Achieving this objective may lead to improved risk stratification or identification of new prevention approaches. We present an overview of current knowledge related to the etiology and pathology of breast cancer. To provide a tangible basis for discussion, we describe two ongoing projects in which spectroscopic analysis of fixed and frozen breast tissues could advance the goals of etiologic research. First, we present a mammographic density study that attempts to identify features of radiologically dense breast tissue that mediate a profound increase in breast cancer risk. Next, we describe a large population-based case-control of breast cancer, which is part of an international consortium, whose joint efforts have to the identification of genetic susceptibility loci for breast cancer and an enhanced understanding of risk factor heterogeneity for this tumor.
Gretchen Gierach, PhD Mark Sherman, MD , NIH/ NCI Division of Cancer Epidemiology & Genetics,.
Physics Building, Rm. 221/ B145. (NIST Contact: Angela Hight Walker, 301-975-2155, ahight@nist.gov)



5/27 -- WEDNESDAY

10:00 AM - PED SEMINAR SERIES: Uncertainty Budget for Range Calibration
The Guide to the Expression of Uncertainty in Measurement established a common procedure to evaluate measurement uncertainty. The Guide covers only the evaluation of a single result or a set of results so far. Modern measurement instruments and procedures operate over a wide range of values. Therefore a procedure is needed in practice to calibrate this range and evaluate an uncertainty for this calibration and the later measurements performed with the calibrated instrument. Traditional regression is used for this purpose. In this talk we will discuss the weaknesses of the regression approach and suggest an alternative to overcome the weaknesses.
Ruediger Kessel , Guest Researcher, Mathematical and Computational Sciences Division, ITL, rudiger@nist.gov.
219 Bldg, Rm. A045. (NIST Contact: John Kramar, 301-975-3447, john.kramar@nist.gov)


10:30 AM - BIOCHEMICAL SCIENCE DIVISION SEMINAR: Factors Affecting Detection of Pathogenic E. coli and Salmonella in Mixed Cultures
Enteric pathogens, such as pathogenic E. coli and Salmonella are estimated to account for over one million cases of gastrointestinal illness annually. Although the vast majority of cases are not fatal, occasional deaths have been reported, particularly for the enterohemorrhagic E. coli (e.g., E. coli O15:H7). At least five groups of pathogenic E. coli have been described based on infection site, symptoms and virulence factors: enterohemorrhagic E. coli (EHEC) enteropathogenic E. coli (EPEC), enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC) and diffusely adherent E. coli (DAEC). Because EHEC are the most virulent, research has focused on characterization of these strains and their prevalence in the environment. Although E. coli serotype O157:H7 is the most common strain, at least six non-O157 serogroups are considered of importance (O26, O43, O103, O111, O121, O143); these strains may be under represented due to the absence of a selective medium. The most virulent EHEC strains carry the virulence genes for shiga toxin production (stx1 and/or stx2), attachment to intestinal walls (eae, tir), and hemolysin (hly). Immunoassays have been developed for detection of different serogroups and/or PCR assays for virulence genes; however, each of these factors is widely distributed among generic, non-pathogenic E. coli. Consequently, there is no single factor, or, as yet, combination of factors that can definitively identify EHEC in a mixed microbial culture. However, based on the quantitative nature of real-time PCR, one may infer the presence of EHEC if the concentrations of all virulence factors are identical. Salmonella appears to be less problematic. Cell surface invasions (e.g., invA), which appear to be both unique to Salmonella and also common to all Salmonella strains can be detected via real-time PCR. However, PCR assays frequently give a positive result in mixed cultures where subsequent isolation is impossible due to competition for growth in enrichment or detection media. Consequently, the question arises: can detection by immunological or nucleic acid based techniques without concomitant isolation of a culture be accepted as an unequivocal positive result?
Dan Shelton , Research Leader. Jeff Karns , Microbiologist. JoAnne van Kessel, Animal Scientist
227 Bldg, Rm. A202. (NIST Contact: Jayne Morrow, 301-975-6722, jayne.morrow@nist.gov)



5/28 -- THURSDAY

10:30 AM - OPTICAL TECHNOLOGY DIVISION SEMINAR: Structure/Function Studies on Bacteriophage Lysins
Great progress has been made the past several years on the discovery (cloning, expression, purification) of lysins and initial evaluation of their therapeutic potential in animal models of colonization. The Nelson group is now interested in studying a small subset of these lysins in detail to understand their basic structures, mechanisms, functions, and evolution. Based on our accumulated data and that of others, we can make a few generalized statements about these enzymes. Lysins from bacteriophage that infect Gram-positive organisms are modular enzymes composed of one or more conserved catalytic domains and a cell wall binding domain (CBD). The catalytic domain is represented by one of four families of peptidoglycan hydrolases: N-acetylglucosaminidases, N-acetylmuramidases (lysozymes), N-acetylmuramoyl-L-alanine amidases, and endopeptidases. In contrast, the CBDs are notably divergent and can distinguish discrete epitopes present within the cell wall, typically carbohydrates, giving rise to the species- or strain-specific activity of a particular lysin. Our research focuses on four inter-related projects; (1) Identification of lysin binding receptors; (2) Lysin tructure/function/mechanism; (3) Lysin kinetics (4) Lysin diagnostics. Direct administration of lysins to susceptible bacteria results in lysis, liberating cytoplamic ATP, which can be measured in a luciferin/luciferase based assay. Using this premise, we can discern as few as 10 streptococcal colony forming units in a background of non-target organisms using a commercial hand-held luminometer. In an alternative diagnostic approach, we are using fluorogenic tags crosslinked to CBDs in order to visualize and quantitate target organisms as well as the ability to employ flow cytometry for bacterial detection. Finally, we have started to crosslink quantum dots to CBDs, which offers perhaps the greatest sensitivity in diagnostic research.
Daniel Nelson , Assistant Professor, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute.
221 Bldg, Rm. B145. (NIST Contact: Jeeseong Hwang, 301-975-4580, jch@nist.gov)


10:30 AM - CNST ELECTRON PHYSICS GROUP SEMINAR: DEVELOPMENT OF A SCANNING TUNNELING POTENTIOMETRY SYSTEM FOR MEASUREMENT OF ELECTRONIC TRANSPORT AT SHORT LENGTH SCALES
It is clear that complete understanding of macroscopic properties of materials is impossible without a thorough knowledge of behavior at the smallest length scales. While the past 25 years have witnessed major advances in a variety of techniques that probe the nanoscale properties of matter, electrical transport measurements – the heart of condensed matter research – have lagged behind, rarely progressing beyond bulk measurements. This thesis describes a scanning tunneling potentiometry (STP) system developed to simultaneously map the transport-related electrochemical potential distribution of a biased sample along with its surface topography, extending electronic transport measurements to the nanoscale. Combining a novel sample biasing technique with a continuous current-nulling feedback scheme pushes the noise performance of the measurement to its fundamental limit - the Johnson noise of the STM tunnel junction. The resulting 130 nV voltage sensitivity allows us to spatially resolve local potentials at scales down to 2 nm, while maintaining atomic scale STM imaging, all at scan sizes of up to 15 microns. A mm-range two-dimensional coarse positioning stage and the ability to operate from liquid helium to room temperature with a fast turn-around time greatly expand the versatility of the instrument. Use of carefully selected model materials, combined with excellent topographic and voltage resolution has allowed us to distinguish measurement artifacts caused by surface roughness from true potentiometric features, a major problem in previous STP measurements. The measurements demonstrate that STP can produce physically meaningful results for homogeneous transport as well as non-uniform conduction dominated by material microstructures. The results establish scanning tunneling potentiometry as a useful tool for physics and materials science.
Michael Rozler , Ph.D. Candidate/ Stanford University.
Bldg.217, Rm.H107. (NIST Contact: Rachel Cannara, 301-975-4258, rachel.cannara@nist.gov)



5/29 -- FRIDAY

10:30 AM - NIST COLLOQUIUM SERIES: Quantum Complexity and Fundamental Physics
What are the ultimate limits on what can feasibly be computed in the physical world? In this talk, I'll try to show how this question ties together many of the central concerns of math, computer science, and physics. I'll also explain how research in quantum computing has transformed our understanding of the question over the last fifteen years. Finally, I'll offer a concrete conjecture---that there is no physical means to solve certain computationally complex problems (NP-complete)---and discuss the evidence for this conjecture, as well as the implications for physics if it's accepted.
Scott Aaronson , Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology.
Administration Building, Green Auditorium. (NIST Contact: Kum Ham, 301-975-4203, kham@nist.gov)
Special Assistance Available


10:45 AM - NIST CENTER FOR NEUTRON RESEARCH SEMINAR: High Power Fuel Cells and Lithium Ion Batteries
Batteries are a key technology for today's and tomorrow's electronic devices. Fuel cells are a key element in a future hydrogen economy, offering the potential to revolutionize current power technologies. Since fuel cells have a high specific energy (kWh/kg), while batteries have high specific power (kW/kg), an internal (intrinsic) fuel cell/battery power source has been investigated by us through incorporating energy storage materials into catalyst layer of fuel cells. In addition, high energy Si anodes (capacity is 10 times higher than currently used carbon anode) and high power LiFePO4 cathodes (electrodes can be charged/discharged in a few seconds) for Li-ion batteries are also developed in our Lab to satisfy the requirements for EV/HEV applications.
Chunsheng Wang , University of Maryland, College Park, MD. ,.
235 Bldg, Rm. E100. (NIST Contact: Daniel Hussey, 301-975-6465, daniel.hussey@nist.gov)


1:30 PM - OPTICAL TECHNOLOGY DIVISION: Manipulating Motion with Light: Optical Gradient Forces in Double-disk Microcavities
Optical forces have been utilized in wide-ranging applications, from optical tweezing to laser cooling, for nearly forty years. In free space these optical forces are relatively weak, but when combined with the high field intensities present in high-quality factor optical microcavities, they give rise to a rich variety of novel physical phenomena and potential applications. I will give a brief overview of the current state of optomechanical research, then will move on to discuss our work utilizing the optical gradient force to demonstrate coherent mechanical oscillation, highly efficient self-cooling, broadband wavelength routing, and fast optical switching in double-microdisk nano-optomechanical systems.
Jessie Rosenberg , PhD Candidate, Caltech Applied Physics,.
Physics Building, Rm. 221/ B145. (NIST Contact: Angela Hight Walker, 301-975-2155, ahight@nist.gov)



ADVANCE NOTICE

6/1/09 2:30 PM - ELECTRON AND OPTICAL PHYSICS DIVISION SEMINAR: "EUV Lithography: The Transition to High Volume Manufacturing for the Next Generation Lithography"
Extreme ultraviolet lithography (EUVL) is the leading candidate for the "next-generation lithography" which will replace optical deep-ultraviolet lithography (DUVL) for production of leading edge semiconductor circuits in about 2012. EUVL differs from DUVL in many important ways that have created major technological challenges for the lithography tool manufacturers. ASML, one of the world's leading producers of DUVL steppers, has been a pioneer in the R&D for EUVL and has built the first pre-production, full-field alpha tools now being used by industry as they get ready to enter a new era and continue following the trajectory of Moore's law into the second decade of the 21st century. Ms. Harned will provide an overview of the challenges that have been addressed and the status of the technology and its realization in a system that will be shipped to leading IC manufacturers in H2 2010.
Noreen Harned , Vice President of Marketing Technology, & New Business, ASML NV, Wilton, CT.
Radiation Physics (Bldg. 245), Rm. C301. (NIST Contact: Thomas Lucatorto, 301-975-3734, thomas.lucatorto@nist.gov)


6/4/09 1:30 PM - STANDARDS ALUMNI ASSOCIATION AND ELECTRON AND OPTICAL PHYSICS DIVISION COLLOQUIUM: Ted Madey: Boy Scout, Friend, Scientist Superb, Shrewd Operator, or All of the Above?
Former NBS/NIST researcher, Theodore Madey was an internationally renowned prime mover in the 1960's-80's transformation of surface science from a mostly empirically-based soft science on poorly characterized systems to a theoretically-supported atomic-scale hard science of well defined systems. From 1988 until his death in 2008, he was the director of the Laboratory for Surface Modification and State of New Jersey Professor of Surface Science at Rutgers University. As former colleagues, collaborators, and friends of Ted, we will each offer our own reflections on mostly NBS/NIST-connected aspects of Ted's life, both scientific and humanistic, drawing heavily on amusing and/or informative anecdotal vignettes that we were involved in with Ted.
J. William Gadzuk , Electron and Optical Physics Division. John Yates , University of Virginia, Charlottesville, VA.
215 Bldg, Rm. C103-C106. (NIST Contact: Helen Felrice, 301-975-3708, helen.felrice@nist.gov)
Special Assistance Available


6/5/09 3:00 PM - CNST NANOFABRICATION RESEARCH GROUP SEMINAR: 3D nanoscopy with a double-helix microscope
Abstract: Double-helix point spread function (DH-PSF) is an engineered three-dimensional (3D) PSF specifically designed for 3D position estimation and imaging. It exhibits two lobes that rotate continuously around the optical axis with propagation. An information theoretical analysis shows that the DH-PSF carries higher and more uniform Fisher Information about a particle's 3D position than the PSF of traditional imaging systems. Experiments with DH-PSF demonstrate nanometer scale 3D position localization precisions. Further, a variety of two-dimensional microscope modalities such as bright-field, dark-field, and fluorescence can be directly transformed into their 3D counterparts by placing a DH-PSF phase mask in their imaging paths. Using photoactivatable fluorophores with a DH-PSF microscope opens up avenues for improving 3D imaging resolution beyond the optical diffraction limit. Bio: Sri Rama "Prasanna" Pavani is a doctoral student in the department of Electrical and Computer Engineering at the University of Colorado - Boulder, where he is a CDM Optics fellow and a COSI Associate fellow. Prasanna's primary research interest is in developing computational optical sensing and imaging (COSI) systems to capture information that is normally lost in traditional imaging systems. In the last few years, he has applied the COSI paradigm to applications like quantitative phase imaging, 3D PSF engineering, 3D tracking / velocimetry, and recently to 3D superresolution imaging. His doctoral research has been recognized with an OSA outstanding paper award, a SPIE optical science and engineering scholarship, and two Colorado Photonics Industry Association best poster awards. More information on Prasanna's research can be found here: http://eces.colorado.edu/~pavani/
Sri Rama Prasanna Pavani , Dept. of Electrical and Computer Engineering, University of Colorado at Boulder.
Bldg. 217, Rm. H107. (NIST Contact: Andrew Berglund, 301-975-2844, andrew.berglund@nist.gov)


6/18/09 10:30 AM - CNST ELECTRON PHYSICS GROUP SEMINAR: APPLYING NANOTRIBOLOGY TO MICRO AND NANOMECHANICAL DEVICES
The reduced length scale of contacts in micro- and nano-electromechanical systems (M/NEMS) and atomic force microscopy (AFM)-based applications leads to tremendous increases in contact stresses, adhesive interactions, friction, tribochemical reactions, and wear. These phenomena are yet to be well-understood or controlled, creating a critical scientific challenge for the development and commercialization of these micro- and nano-technologies. I will discuss specific applications where these factors are critical, including nanomanufacturing, nanomechanical data storage, and MEMS and NEMS switches. I will then discuss experimental methodologies for measuring and understanding nanoscale tribology through combinations of AFM, other microscopies, and surface spectroscopic techniques. I will then highlight recent measurements that demonstrate how nanotribological phenomena are related to surface atomic bonding and environmental conditions. Particular emphasis will be placed on how the use of materials with excellent macroscopic tribo-mechanical properties, including diamond and diamond-like films, can provide dramatic improvements compared with silicon-based materials which are more commonly used in nanoscale applications currently.
Robert Carpick , Director, The Nanotechnology Institute, University of Pennsylvania.
Bldg.217, Rm.H107. (NIST Contact: Rachel Cannara, 301-975-4258, rachel.cannara@nist.gov)


6/22/09 10:30 AM - CNST ELECTRON PHYSICS GROUP SEMINAR: CATALYTIC CVD GROWTH OF CARBON NANOTUBES AND THEIR APPLICATION AS CHEMICAL SENSORS
Carbon based materials come in a variety of different forms that depend on how their atoms link together, such as zero-dimensional fullerenes, one-dimensional nanotubes, two-dimensional (2-D) graphene and three-dimensional (3-D) graphite. The properties of these carbon based materials can be tailored by irradiation and chemical functionalization to use them for various applications. In recent years, carbon nanotubes (CNTs) have been a subject of increased interest especially because of their exceptional thermal, electrical and mechanical properties which far exceed those of most bulk materials. However inspite of considerable progress in the synthesis of CNTs there still exist significant challenges like production of nanotube materials with controlled diameter, length, orientation, location and microstructure. Thus there is a need to understand the growth mechanisms of both multiwalled and singlewalled carbon nanotubes in order to synthesize them in a controlled manner. The high electrical conductivity and surface area of CNTs is motivating their application as chemical sensors. We present here a systematic study of molecular adsorption on SWNTs by measurements of the conductivity response of single walled carbon nanotube (SWNT) arrays to trace vapors for a range of linear chain and aromatic molecules. Ab initio calculations were performed with density functional theory methods to investigate the molecular adsorption of these molecules on SWNTs. Both conductance measurements and Ab initio calculations show that the adsorption energies of linear alkane, alcohol and ketone molecules increase linearly with the length of the molecule. These results indicate that the initial adsorption and conductivity response occurs with molecules predominantly lying flat on the defect-free nanotube side walls and the long time response is dominated by adsorption at defects. The difference in the conductivity responses for polar and non polar adsorbates is attributed to changes in scattering due to adsorbates. Further experiments with random arrays of carbon nanotubes reveal a strong conductivity response after exposure to aromatic molecules containing nitro functional groups, such as nitrobenzene and trinitrotoluene. Ab initio calculations also show a strong increase in adsorption energy with the addition of each nitro group to a molecule (around 100 meV) and a gradual increase with nanotube size, in agreement with preliminary experimental results. Finally, these calculations are compared with results for the adsorption at oxidation defects.
Navdeep Bajwa , Postdoctoral Fellow, The US Naval Research Laboratory.
Bldg.217, Rm.H107. (NIST Contact: Rachel Cannara, 301-975-4258, rachel.cannara@nist.gov)



MEETINGS ELSEWHERE



5/25 -- MONDAY

No Scheduled Events

5/26 -- TUESDAY

No Scheduled Events

5/27 -- WEDNESDAY

No Scheduled Events

5/28 -- THURSDAY

No Scheduled Events

5/29 -- FRIDAY

No Scheduled Events

ADVANCE NOTICE

No Scheduled Events

TALKS BY NIST PERSONNEL


READER, J. : SOFT X-RAY SPECTRA OF HIGHLY CHARGED HF, TA, W, AND AU*.
Meeting of the Division of Atomic, Molecular, and Optical Physics(DAMOP), Charlottesville, Virginia USA, 5/21.

SAUNDERS, B. : TENSOR PRODUCT GRID GENERATION FOR COMPLEX SURFACE VISUALIZATOINS IN A DIGITAL LIBRARY OF MATHEMATICAL FUNCTIONS.
Eleventh International Society for Grid Generation Conference (ISGG), Montreal, Canada, 5/26.

SOLES, C. : A COMPETITION BETWEEN VERTICAL AND LATERAL INSTABILITIES IN PARALLEL LANE SOURCE GRATINGS FABRICATED BY NIL.
EIPBN, Marco Island,FL, 5/27.

SEMANCIK, S. : GENERATING AND USING DATA OF HIGHER DIMENSION FOR GAS-PHASE CHEMICAL SENSING.
215th Meeting of the Electrochemical Society, Hilton San Francisco Hotel, San Francisco, CA, 5/27.

TSANG, W. : CHEMICAL KINETICS DATABASE FOR COMBUSTION MODELING.
30th Annual Combustion Contractors Meeting/Airlie House, Warrenton, VA, 5/27.



ANNOUNCEMENTS


BALDRIGE TRAINING AT NIST
The Baldrige National Quality Program will be hosting its Examiner Preparation course for its board of Examiners each Tuesday through Friday beginning April 28 to May 22. Approximately 130 or more Examiners will be attending each week. The Baldrige Examiners will be eating breakfast in the cafeteria each day beginning at 7:15 a.m. They will use the West end serving area of the cafeteria for lunches in order to alleviate congestion in the main cafeteria serving area. Should you have any questions or concerns, please contact Jackie DesChamps at ext. 3771.
NIST Contact: Jacqueline Deschamps, 301-975-3771, jacqueline.deschamps@nist.gov


PUBLICATIONS PRINTING DEADLINE AUGUST 14, 2009
August 14 is the last day in FY 2009 to submit materials using FY 2009 funds to the Electronic Information and Publications Group (EIPG) for printing at the Department of Commerce or Government Printing Office. To assure timely processing, bring your Editorial Review Board-approved document or administrative printing job and appropriate paperwork to the EIPG office by close of business on Friday, August 14, 2009. The office is located on the mezzanine floor of the NIST Research Library in the Administration Building, Room E220. Questions? Ilse Putman, x2780 or Barbara Silcox, x2146.
NIST Contact: Ilse Putman, 301-975-2780, ilse.putman@nist.gov




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NIST Contact: nancy allmang, 301-975-4189, nancy.allmang@nist.gov



For more information, contact Ms. Sharon Hallman, Editor, Stop 2500, National Institute of Standards and Technology, Gaithersburg MD 20899-2500; Telephone: 301-975-TCAL (3570); Fax: 301-926-4431; or Email: tcal@nist.gov.

All lectures and meetings are open unless otherwise stated.

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